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1.

Allele-specific expression of GATA2 due to epigenetic dysregulation in CEBPA double-mutant AML.

Mulet-Lazaro, Roger; van Herk, Stanley; Erpelinck, Claudia; Bindels, Eric; Sanders, Mathijs A; Vermeulen, Carlo; Renkens, Ivo; Valk, Peter; Melnick, Ari M; de Ridder, Jeroen; Rehli, Michael; Gebhard, Claudia; Delwel, Ruud; Wouters, Bas J.

Blood ; 138(2): 160-177, 2021 07 15.

Artículo en Inglés | MEDLINE | ID: mdl-33831168

2.

BCL6 maintains survival and self-renewal of primary human acute myeloid leukemia cells.

Kawabata, Kimihito C; Zong, Hongliang; Meydan, Cem; Wyman, Sarah; Wouters, Bas J; Sugita, Mayumi; Goswami, Srinjoy; Albert, Michael; Yip, Winnie; Roboz, Gail J; Chen, Zhengming; Delwel, Ruud; Carroll, Martin; Mason, Christopher E; Melnick, Ari; Guzman, Monica L.

Blood ; 137(6): 812-825, 2021 02 11.

Artículo en Inglés | MEDLINE | ID: mdl-32911532

3.

Epigenetics and approaches to targeted epigenetic therapy in acute myeloid leukemia.

Wouters, Bas J; Delwel, Ruud.

Blood ; 127(1): 42-52, 2016 Jan 07.

Artículo en Inglés | MEDLINE | ID: mdl-26660432

4.

Hitting the target in IDH2 mutant AML.

Wouters, Bas J.

Blood ; 130(6): 693-694, 2017 08 10.

Artículo en Inglés | MEDLINE | ID: mdl-28798056

5.

Tribbles homolog 2 inactivates C/EBPalpha and causes acute myelogenous leukemia.

Keeshan, Karen; He, Yiping; Wouters, Bas J; Shestova, Olga; Xu, Lanwei; Sai, Hong; Rodriguez, Carlos G; Maillard, Ivan; Tobias, John W; Valk, Peter; Carroll, Martin; Aster, Jon C; Delwel, Ruud; Pear, Warren S.

Cancer Cell ; 10(5): 401-11, 2006 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-17097562

6.

Risk stratification of intermediate-risk acute myeloid leukemia: integrative analysis of a multitude of gene mutation and gene expression markers.

Rockova, Veronika; Abbas, Saman; Wouters, Bas J; Erpelinck, Claudia A J; Beverloo, H Berna; Delwel, Ruud; van Putten, Wim L J; Löwenberg, Bob; Valk, Peter J M.

Blood ; 118(4): 1069-76, 2011 Jul 28.

Artículo en Inglés | MEDLINE | ID: mdl-21596848

7.

Prognostic impact, concurrent genetic mutations, and gene expression features of AML with CEBPA mutations in a cohort of 1182 cytogenetically normal AML patients: further evidence for CEBPA double mutant AML as a distinctive disease entity.

Taskesen, Erdogan; Bullinger, Lars; Corbacioglu, Andrea; Sanders, Mathijs A; Erpelinck, Claudia A J; Wouters, Bas J; van der Poel-van de Luytgaarde, Sonja C; Damm, Frederik; Krauter, Jürgen; Ganser, Arnold; Schlenk, Richard F; Löwenberg, Bob; Delwel, Ruud; Döhner, Hartmut; Valk, Peter J M; Döhner, Konstanze.

Blood ; 117(8): 2469-75, 2011 Feb 24.

Artículo en Inglés | MEDLINE | ID: mdl-21177436

8.

A decade of genome-wide gene expression profiling in acute myeloid leukemia: flashback and prospects.

Wouters, Bas J; Löwenberg, Bob; Delwel, Ruud.

Blood ; 113(2): 291-8, 2009 Jan 08.

Artículo en Inglés | MEDLINE | ID: mdl-18703705

9.

Double CEBPA mutations, but not single CEBPA mutations, define a subgroup of acute myeloid leukemia with a distinctive gene expression profile that is uniquely associated with a favorable outcome.

Wouters, Bas J; Löwenberg, Bob; Erpelinck-Verschueren, Claudia A J; van Putten, Wim L J; Valk, Peter J M; Delwel, Ruud.

Blood ; 113(13): 3088-91, 2009 Mar 26.

Artículo en Inglés | MEDLINE | ID: mdl-19171880

10.

Gene expression profiling of minimally differentiated acute myeloid leukemia: M0 is a distinct entity subdivided by RUNX1 mutation status.

Silva, Fernando P G; Swagemakers, Sigrid M A; Erpelinck-Verschueren, Claudia; Wouters, Bas J; Delwel, Ruud; Vrieling, Harry; van der Spek, Peter; Valk, Peter J M; Giphart-Gassler, Micheline.

Blood ; 114(14): 3001-7, 2009 Oct 01.

Artículo en Inglés | MEDLINE | ID: mdl-19666867

11.

Genome-wide epigenetic analysis delineates a biologically distinct immature acute leukemia with myeloid/T-lymphoid features.

Figueroa, Maria E; Wouters, Bas J; Skrabanek, Lucy; Glass, Jacob; Li, Yushan; Erpelinck-Verschueren, Claudia A J; Langerak, Anton W; Löwenberg, Bob; Fazzari, Melissa; Greally, John M; Valk, Peter J M; Melnick, Ari; Delwel, Ruud.

Blood ; 113(12): 2795-804, 2009 Mar 19.

Artículo en Inglés | MEDLINE | ID: mdl-19168792

12.

HAT: hypergeometric analysis of tiling-arrays with application to promoter-GeneChip data.

Taskesen, Erdogan; Beekman, Renee; de Ridder, Jeroen; Wouters, Bas J; Peeters, Justine K; Touw, Ivo P; Reinders, Marcel J T; Delwel, Ruud.

BMC Bioinformatics ; 11: 275, 2010 May 21.

Artículo en Inglés | MEDLINE | ID: mdl-20492700

13.

Prediction of molecular subtypes in acute myeloid leukemia based on gene expression profiling.

Verhaak, Roel G W; Wouters, Bas J; Erpelinck, Claudia A J; Abbas, Saman; Beverloo, H Berna; Lugthart, Sanne; Löwenberg, Bob; Delwel, Ruud; Valk, Peter J M.

Haematologica ; 94(1): 131-4, 2009 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-18838472

14.

Therapeutic Targeting of RNA Splicing Catalysis through Inhibition of Protein Arginine Methylation.

Fong, Jia Yi; Pignata, Luca; Goy, Pierre-Alexis; Kawabata, Kimihito Cojin; Lee, Stanley Chun-Wei; Koh, Cheryl M; Musiani, Daniele; Massignani, Enrico; Kotini, Andriana G; Penson, Alex; Wun, Cheng Mun; Shen, Yudao; Schwarz, Megan; Low, Diana Hp; Rialdi, Alexander; Ki, Michelle; Wollmann, Heike; Mzoughi, Slim; Gay, Florence; Thompson, Christine; Hart, Timothy; Barbash, Olena; Luciani, Genna M; Szewczyk, Magdalena M; Wouters, Bas J; Delwel, Ruud; Papapetrou, Eirini P; Barsyte-Lovejoy, Dalia; Arrowsmith, Cheryl H; Minden, Mark D; Jin, Jian; Melnick, Ari; Bonaldi, Tiziana; Abdel-Wahab, Omar; Guccione, Ernesto.

Cancer Cell ; 36(2): 194-209.e9, 2019 08 12.

Artículo en Inglés | MEDLINE | ID: mdl-31408619

15.

Gene expression profiling for improved dissection of acute leukemia: a recently identified immature myeloid/T-lymphoid subgroup as an example.

Wouters, Bas J; Koss, Clara; Delwel, Ruud.

Blood Cells Mol Dis ; 40(3): 395-400, 2008.

Artículo en Inglés | MEDLINE | ID: mdl-18096415

16.

Text-derived concept profiles support assessment of DNA microarray data for acute myeloid leukemia and for androgen receptor stimulation.

Jelier, Rob; Jenster, Guido; Dorssers, Lambert C J; Wouters, Bas J; Hendriksen, Peter J M; Mons, Barend; Delwel, Ruud; Kors, Jan A.

BMC Bioinformatics ; 8: 14, 2007 Jan 18.

Artículo en Inglés | MEDLINE | ID: mdl-17233900

17.

Minimal Residual Disease Monitoring of Acute Myeloid Leukemia by Massively Multiplex Digital PCR in Patients with NPM1 Mutations.

Mencia-Trinchant, Nuria; Hu, Yang; Alas, Maria Antonina; Ali, Fatima; Wouters, Bas J; Lee, Sangmin; Ritchie, Ellen K; Desai, Pinkal; Guzman, Monica L; Roboz, Gail J; Hassane, Duane C.

J Mol Diagn ; 19(4): 537-548, 2017 07.

Artículo en Inglés | MEDLINE | ID: mdl-28525762

18.

Epigenetic Identity in AML Depends on Disruption of Nonpromoter Regulatory Elements and Is Affected by Antagonistic Effects of Mutations in Epigenetic Modifiers.

Glass, Jacob L; Hassane, Duane; Wouters, Bas J; Kunimoto, Hiroyoshi; Avellino, Roberto; Garrett-Bakelman, Francine E; Guryanova, Olga A; Bowman, Robert; Redlich, Shira; Intlekofer, Andrew M; Meydan, Cem; Qin, Tingting; Fall, Mame; Alonso, Alicia; Guzman, Monica L; Valk, Peter J M; Thompson, Craig B; Levine, Ross; Elemento, Olivier; Delwel, Ruud; Melnick, Ari; Figueroa, Maria E.

Cancer Discov ; 7(8): 868-883, 2017 08.

Artículo en Inglés | MEDLINE | ID: mdl-28408400

19.

A transcriptional profiling study of CCAAT/enhancer binding protein targets identifies hepatocyte nuclear factor 3 beta as a novel tumor suppressor in lung cancer.

Halmos, Balazs; Bassères, Daniela S; Monti, Stefano; D'Aló, Francesco; Dayaram, Tajhal; Ferenczi, Katalin; Wouters, Bas J; Huettner, Claudia S; Golub, Todd R; Tenen, Daniel G.

Cancer Res ; 64(12): 4137-47, 2004 Jun 15.

Artículo en Inglés | MEDLINE | ID: mdl-15205324

20.

Targeting IDH1 and IDH2 Mutations in Acute Myeloid Leukemia: Emerging Options and Pending Questions.